1-(2,4-Xylyl)piperazine → HCID 58484574, compound

HRID 2411268Notes

Reaction equation

HRID 2411268 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH3:11][C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([N:22]2[CH2:23][CH2:24][N:19]([C:13]3[CH:14]=[CH:15][C:16]([CH3:18])=[CH:17][C:12]=3[CH3:11])[CH2:20][CH2:21]2)=[O:10])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 6085445-Bromopyridine-2-carboxylic acid

Product 1

HCID 58484574HCID 58484574, compoundYield 101.5%

Procedure

Using 5-bromopyridine-2-carboxylic acid (5 g) and 1-(2,4-dimethylphenyl)piperazine (4.8 g) and by the reaction and treatment in the same manner as in Preparation Example 109, the title compound (9.4 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 109

Sources & evidence

ORD record
ord-9e10ca18881c4a88bda384dc2fdc805b
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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