5-Bromopyridine-2-carboxylic acid → HCID 71252484, compound

HRID 2411273Notes

Reaction equation

HRID 2411273 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH:11]1([C:14]2[C:15]([N:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)=[N:16][CH:17]=[C:18]([CH:20]3[CH2:22][CH2:21]3)[CH:19]=2)[CH2:13][CH2:12]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([N:26]2[CH2:27][CH2:28][N:23]([C:15]3[C:14]([CH:11]4[CH2:12][CH2:13]4)=[CH:19][C:18]([CH:20]4[CH2:22][CH2:21]4)=[CH:17][N:16]=3)[CH2:24][CH2:25]2)=[O:10])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 6085445-Bromopyridine-2-carboxylic acidHCID 584847011-(3,5-Dicyclopropylpyridin-2-yl)piperazine

Product 1

HCID 71252484HCID 71252484, compoundYield 99.8%

Procedure

Using 5-bromo-2-picolinic acid (378 mg) and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine (500 mg) described in Preparation Example 88 and by the reaction and treatment in the same manner as in Preparation Example 109, the title compound (798 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 88 and by the reaction and treatment in the same manner as in Preparation Example 109

Sources & evidence

ORD record
ord-ae3bf125d68245c085ae329e4b736617
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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