HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → [4-(2,4-Dimethylphenyl)piperazin-1-yl](6-iodopyridin-3-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | HCID 58484755 | HCID 58484755 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Product | [4-(2,4-Dimethylphenyl)piperazin-1-yl](6-iodopyridin-3-yl)methanone | HCID 86676763 | 62.1% |
Reaction Steps
Using (6-bromopyridin-3-yl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (487 mg) described in Preparation Example 115, sodium iodide (389 mg) and copper(I) iodide (123 mg) and by the reaction and treatment in the same manner as in Preparation Example 154, the title compound (340.6 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-e7f19f13b8dd46d7b4335aae1fe0ab00 |
| Source note | uspto-grants-2014_08 |