2-Fluoro-4-iodobenzoic acid → HCID 71251940, compound

HRID 2411300Notes

Reaction equation

HRID 2411300 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([I:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH:12]1([C:15]2[C:16]([N:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)=[N:17][CH:18]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:20]=2)[CH2:14][CH2:13]1>>[CH:12]1([C:15]2[C:16]([N:24]3[CH2:25][CH2:26][N:27]([C:4]([C:3]4[CH:7]=[CH:8][C:9]([I:11])=[CH:10][C:2]=4[F:1])=[O:6])[CH2:28][CH2:29]3)=[N:17][CH:18]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:20]=2)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 27745162-Fluoro-4-iodobenzoic acidHCID 584847011-(3,5-Dicyclopropylpyridin-2-yl)piperazine

Product 1

HCID 71251940HCID 71251940, compoundYield 92.9%

Procedure

Using 2-fluoro-4-iodobenzoic acid (2.027 g) and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine (1.85 g) described in Preparation Example 88 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (3.47 g) was obtained.

Workup

  1. customdescribed in Preparation Example 88 and by the reaction and treatment in the same manner as in Preparation Example 111

Sources & evidence

ORD record
ord-8f22820a076744ff96034ba2abca47c8
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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