HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Bromo-2-cyanobenzoic acid → 5-Bromo-2-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Bromo-2-cyanobenzoic acid | HCID 58484585 | — |
| Edukt | 1-(3,5,6-Trimethylpyridin-2-yl)piperazine | HCID 58484823 | — |
| Produkt | 5-Bromo-2-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile | HCID 71252174 | 87,9% |
Reaktionsschritte
Using 4-bromo-2-cyanobenzoic acid (3.84 g) described in Preparation Example 76 and 1-(3,5,6-trimethylpyridin-2-yl)piperazine (3.66 g) described in Preparation Example 92 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (6.17 g) was obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08816079B2 |
| Quelldatensatz | uspto-grants-2014_08 |
| ORD ID | ord-40e72af43e344d2ebe3ba2aeb4fbf94e |
| Quellennotiz | uspto-grants-2014_08 |