HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Fluoro-4-methylpyridine-3-carboxylic acid → [4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Fluoro-4-methylpyridine-3-carboxylic acid | HCID 46739274 | — |
| Reactant | 1-(3,5-Dicyclopropylpyridin-2-yl)piperazine | HCID 58484701 | — |
| Product | [4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone | HCID 58484583 | 85.5% |
Reaction Steps
Using 6-fluoro-4-methylnicotinic acid (0.60 g) and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine (0.92 g) described in Preparation Example 88 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (1.23 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-9693b085072d41bf848736040a3a6b74 |
| Source note | uspto-grants-2014_08 |