1-(2,4-Xylyl)piperazine → HCID 58484738, compound

HRID 2411311Notes

Reaction equation

HRID 2411311 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[N:20]1[CH2:21][CH2:22][N:23]([C:6]([C:5]2[CH:4]=[N:3][C:2]([F:1])=[CH:10][C:9]=2[CH3:11])=[O:8])[CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acid

Product 1

HCID 58484738HCID 58484738, compoundYield 83.3%

Procedure

Using 6-fluoro-4-methylnicotinic acid (500 mg) and 1-(2,4-dimethylphenyl)piperazine (607 mg) and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (870 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 111

Sources & evidence

ORD record
ord-b1c82003613c4f6291d1e36b3ebda24e
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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