HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Fluoro-4-methylpyridine-3-carboxylic acid → [4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Fluoro-4-methylpyridine-3-carboxylic acid | HCID 46739274 | — |
| Reactant | 1-(5-Ethyl-3-methylpyridin-2-yl)piperazine | HCID 58484578 | — |
| Product | [4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone | HCID 58484602 | 52.4% |
Reaction Steps
Using 6-fluoro-4-methylnicotinic acid (300 mg) and 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (389 mg) described in Preparation Example 81 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (340 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-d95b053da39447158c4699a2af72b684 |
| Source note | uspto-grants-2014_08 |