1,3-Propanesultam → HCID 71252648, compound

HRID 2411313Notes

Reaction equation

HRID 2411313 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]([CH2:12]Br)[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[S:14]1(=[O:20])(=[O:19])[CH2:18][CH2:17][CH2:16][NH:15]1>>[Br:1][C:2]1[CH:11]=[C:10]([CH2:12][N:15]2[CH2:16][CH2:17][CH2:18][S:14]2(=[O:20])=[O:19])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 19806367Methyl 2-bromo-4-(bromomethyl)benzoate

Product 1

HCID 71252648HCID 71252648, compoundYield 55.2%

Procedure

Using methyl 2-bromo-4-bromomethylbenzoate (500 mg) and isothiazolidine 1,1-dioxide (216 mg) and by the reaction and treatment in the same manner as in Preparation Example 42, the title compound (312 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 42

Sources & evidence

ORD record
ord-012f19333b294188843ac91fa2a4de5d
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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