6-Fluoro-4-methylpyridine-3-carboxylic acid → HCID 58484588, compound

HRID 2411315Notes

Reaction equation

HRID 2411315 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH:12]1([C:15]2[CH:20]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:18]=[CH:17][C:16]=2[N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:14][CH2:13]1>>[CH:12]1([C:15]2[CH:20]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:18]=[CH:17][C:16]=2[N:24]2[CH2:25][CH2:26][N:27]([C:6]([C:5]3[CH:4]=[N:3][C:2]([F:1])=[CH:10][C:9]=3[CH3:11])=[O:8])[CH2:28][CH2:29]2)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acidHCID 67381204HCID 67381204, compound

Product 1

HCID 58484588HCID 58484588, compoundYield 103.8%

Procedure

Using 6-fluoro-4-methylnicotinic acid (386 mg) and 1-(2,4-dicyclopropylphenyl)piperazine (650 mg) described in Preparation Example 101 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (980 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 101 and by the reaction and treatment in the same manner as in Preparation Example 118

Sources & evidence

ORD record
ord-2857f953ab9e4c88a45d7b07ef7bb419
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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