1-(2,4,5-Trimethylphenyl)piperazine → HCID 71252409, compound

HRID 2411316Notes

Reaction equation

HRID 2411316 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[C:16]([CH3:20])=[CH:15][C:14]=1[N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[F:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:24]2[CH2:25][CH2:26][N:21]([C:14]3[CH:15]=[C:16]([CH3:20])[C:17]([CH3:19])=[CH:18][C:13]=3[CH3:12])[CH2:22][CH2:23]2)=[O:8])=[C:9]([CH3:11])[CH:10]=1

Participants

3

Reactant 2

HCID 27608211-(2,4,5-Trimethylphenyl)piperazineHCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acid

Product 1

HCID 71252409HCID 71252409, compoundYield 86.9%

Procedure

Using 6-fluoro-4-methylnicotinic acid (162 mg) and 1-(2,4,5-trimethylphenyl)piperazine (230 mg) and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (310 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 118

Sources & evidence

ORD record
ord-f2eff5dc87a946169741d0ad2a1ab9ec
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…