HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromonicotinic acid → 2-[4-(6-Bromopyridine-3-carbonyl)piperazin-1-yl]-5-methylnicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromonicotinic acid | HCID 238932 | — |
| Reactant | 4-(3-Cyano-5-methylpyridin-2-yl)piperazine | HCID 71252289 | — |
| Product | 2-[4-(6-Bromopyridine-3-carbonyl)piperazin-1-yl]-5-methylnicotinonitrile | HCID 86676764 | 79.2% |
Reaction Steps
Using 6-bromonicotinic acid (303 mg) and 4-(3-cyano-5-methylpyridin-2-yl)piperazine (303 mg) described in Preparation Example 107 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (458 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-7eac7b0eb0344ceead57a10fd8a1d035 |
| Source note | uspto-grants-2014_08 |