HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,5-Dimethylpyridin-2-yl)piperazine → 5-Bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,5-Dimethylpyridin-2-yl)piperazine | HCID 58484496 | — |
| Reactant | 4-Bromo-2-cyanobenzoic acid | HCID 58484585 | — |
| Product | 5-Bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile | HCID 58484628 | 81.2% |
Reaction Steps
Using 4-bromo-2-cyanobenzoic acid (3.39 g) described in Preparation Example 76 and 1-(3,5-dimethylpyridin-2-yl)piperazine (3.01 g) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (4.86 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-1f5d7d1a52fa43f5bd08b574f1c6bac3 |
| Source note | uspto-grants-2014_08 |