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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2411330Generated: October 26, 2026

6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(p-tolyloxy)piperidin-1-yl]methanone

https://huagongshe.com/reaction/2411330

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Bromonicotinic acidHCID 238932—
Reactant4-(4-Methylphenoxy)piperidineHCID 3837497—
Product(6-Bromopyridin-3-yl)[4-(p-tolyloxy)piperidin-1-yl]methanoneHCID 5848459199.9%

Reaction Steps

Using 4-(p-tolyloxy)piperidine (765 mg) and 6-bromonicotinic acid (808 mg) and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (1.5 g) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08816079B2
Source datasetuspto-grants-2014_08
ORD IDord-e46681dc325d47bfaf2d19e9ad6d59c7
Source noteuspto-grants-2014_08