1-(3,5-Dichloropyridin-2-yl)piperazine → [4-(3,5-Dichloropyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxyphenyl]methanone

HRID 2411334Notes

Reaction equation

HRID 2411334 reaction equation
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[C:9]([O:16][CH3:17])[CH:8]=1.[Cl:19][C:20]1[C:21]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[N:22][CH:23]=[C:24]([Cl:26])[CH:25]=1>>[Cl:19][C:20]1[C:21]([N:27]2[CH2:32][CH2:31][N:30]([C:11]([C:10]3[CH:14]=[CH:15][C:7]([N:3]4[CH2:4][CH2:5][CH2:6][S:2]4(=[O:1])=[O:18])=[CH:8][C:9]=3[O:16][CH3:17])=[O:13])[CH2:29][CH2:28]2)=[N:22][CH:23]=[C:24]([Cl:26])[CH:25]=1

Participants

3

Reactant 2

HCID 27714311-(3,5-Dichloropyridin-2-yl)piperazineHCID 712520824-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxybenzoic acid

Product 1

HCID 71252081[4-(3,5-Dichloropyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxyphenyl]methanoneYield 106.8%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methoxybenzoic acid (266 mg) described in Preparation Example 19 and 1-(3,5-dichloropyridin-2-yl)piperazine (227 mg) and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (507 mg) was obtained.

Sources & evidence

ORD record
ord-cba5134f0eba4905b1607d25a18eb61d
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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