3-Chloropropanesulphonyl chloride → HCID 71252608, compound

HRID 2411336Notes

Reaction equation

HRID 2411336 reaction equation
[NH2:1][CH2:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([F:13])[CH:4]=1.Cl[CH2:15][CH2:16][CH2:17][S:18](Cl)(=[O:20])=[O:19]>>[O:19]=[S:18]1(=[O:20])[CH2:17][CH2:16][CH2:15][N:1]1[CH2:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([F:13])[CH:4]=1

Participants

3

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 57572260Methyl 4-(aminomethyl)-2-fluorobenzoate

Product 1

HCID 71252608HCID 71252608, compound

Procedure

Using methyl 4-aminomethyl-2-fluorobenzoate (181 mg) described in Preparation Example 199 and 3-chloropropane-1-sulfonyl chloride (0.14 mL) and by the reaction and treatment in the same manner as in Preparation Example 17, the title compound (233 mg) was obtained.

Sources & evidence

ORD record
ord-1064217b806c4442a571be03b2a27286
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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