HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromonicotinic acid | HCID 238932 | — |
| Reactant | 1-(3,5,6-Trimethylpyridin-2-yl)piperazine | HCID 58484823 | — |
| Product | (6-Bromopyridin-3-yl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484612 | 88.2% |
Reaction Steps
Using 6-bromonicotinic acid (606 mg) and 1-(3,5,6-trimethylpyridin-2-yl)piperazine (616 mg) described in Preparation Example 92 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (1.03 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-2ccb286a626c4aabbb35484de828acdc |
| Source note | uspto-grants-2014_08 |