4-Methyloxybenzyl chloride → 5-Isopropyl-3-(4-methoxybenzyl)imidazolidine-2,4-dione

HRID 2411342Notes

Reaction equation

HRID 2411342 reaction equation
[CH:1]([CH:4]1[NH:8][C:7](=[O:9])[NH:6][C:5]1=[O:10])([CH3:3])[CH3:2].[CH3:11][O:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17]Cl)=[CH:15][CH:14]=1>>[CH:1]([CH:4]1[NH:8][C:7](=[O:9])[N:6]([CH2:17][C:16]2[CH:19]=[CH:20][C:13]([O:12][CH3:11])=[CH:14][CH:15]=2)[C:5]1=[O:10])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 699934-Methyloxybenzyl chlorideHCID 1030335-Isopropylhydantoin

Product 1

HCID 712528645-Isopropyl-3-(4-methoxybenzyl)imidazolidine-2,4-dione

Procedure

Using 5-isopropylimidazolidine-2,4-dione (2.00 g) and 4-methoxybenzyl chloride (2.29 mL) and by the reaction and treatment in the same manner as in Preparation Example 51, the title compound (2.72 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 51

Sources & evidence

ORD record
ord-189474c7e3ac4500bdba415a95c91613
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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