4-Bromo-2-fluorobenzoic acid → (4-Bromo-2-fluorophenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

HRID 2411343Notes

Reaction equation

HRID 2411343 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([F:11])[CH:3]=1.[CH2:12]([C:14]1[CH:15]=[C:16]([CH3:26])[C:17]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:18][CH:19]=1)[CH3:13]>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:17]3[C:16]([CH3:26])=[CH:15][C:14]([CH2:12][CH3:13])=[CH:19][N:18]=3)[CH2:21][CH2:22]2)=[O:8])=[C:4]([F:11])[CH:3]=1

Participants

3

Reactant 2

HCID 3026814-Bromo-2-fluorobenzoic acidHCID 584845781-(5-Ethyl-3-methylpyridin-2-yl)piperazine

Product 1

HCID 58484537(4-Bromo-2-fluorophenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneYield 86.1%

Procedure

Using 4-bromo-2-fluorobenzoic acid (1.08 g) and 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (1.01 g) described in Preparation Example 81 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (1.72 g) was obtained.

Workup

  1. customdescribed in Preparation Example 81 and by the reaction and treatment in the same manner as in Preparation Example 111

Sources & evidence

ORD record
ord-ffd99739321e4be9ae98dcf6cb8dc39d
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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