HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Toluenesulfonyl chloride → [(2R)-5-Oxopyrrolidin-2-yl]methyl 4-methylbenzene-1-sulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | (R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone | HCID 7128291 | — |
| Product | [(2R)-5-Oxopyrrolidin-2-yl]methyl 4-methylbenzene-1-sulfonate | HCID 13306710 | 66.4% |
Reaction Steps
Using (R)-5-hydroxymethylpyrrolidin-2-one (1.68 g) and p-toluenesulfonyl chloride (2.92 g) and by the reaction and treatment in the same manner as in Preparation Example 219, the title compound (2.61 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-a7813c03442b436e819f91be025e908a |
| Source note | uspto-grants-2014_08 |