6-chloropyridazine-3-carboxylic Acid → HCID 86676766, compound

HRID 2411357Notes

Reaction equation

HRID 2411357 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([C:8]([OH:10])=O)=[CH:4][CH:3]=1.[CH3:11][C:12]1[C:13]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:14][CH:15]=[C:16]([CH3:18])[CH:17]=1>>[Cl:1][C:2]1[N:7]=[N:6][C:5]([C:8]([N:22]2[CH2:23][CH2:24][N:19]([C:13]3[C:12]([CH3:11])=[CH:17][C:16]([CH3:18])=[CH:15][N:14]=3)[CH2:20][CH2:21]2)=[O:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 64157626-chloropyridazine-3-carboxylic AcidHCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

Product 1

HCID 86676766HCID 86676766, compoundYield 69.2%

Procedure

Using 6-chloropyridazine-3-carboxylic acid (1 g) and 1-(3,5-dimethylpyridin-2-yl)piperazine (1.2 g) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (1.44 g) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 118

Sources & evidence

ORD record
ord-cec3e2d1702e4580b9d1a3b7a363c841
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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