2-Bromo-4-chlorobenzoic acid → HCID 58484687, compound

HRID 2411362Notes

Reaction equation

HRID 2411362 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH:12]1([C:15]2[CH:16]=[C:17]([CH3:27])[C:18]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)=[N:19][CH:20]=2)[CH2:14][CH2:13]1>>[Br:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([N:24]1[CH2:25][CH2:26][N:21]([C:18]2[C:17]([CH3:27])=[CH:16][C:15]([CH:12]3[CH2:13][CH2:14]3)=[CH:20][N:19]=2)[CH2:22][CH2:23]1)=[O:6]

Participants

3

Reactant 2

HCID 331262-Bromo-4-chlorobenzoic acidHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

Product 1

HCID 58484687HCID 58484687, compoundYield 95.1%

Procedure

Using 2-bromo-4-chlorobenzoic acid (1 g) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (0.92 g) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (1.75 g) was obtained.

Workup

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 111

Sources & evidence

ORD record
ord-6842b6e582144687b19ecc3333b42095
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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