2,4-Dibromobenzoic acid → (2,4-Dibromophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

HRID 2411364Notes

Reaction equation

HRID 2411364 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:12][C:13]1[C:14]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:15][CH:16]=[C:17]([CH3:19])[CH:18]=1>>[Br:1][C:2]1[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:3]=1[C:4]([N:23]1[CH2:24][CH2:25][N:20]([C:14]2[C:13]([CH3:12])=[CH:18][C:17]([CH3:19])=[CH:16][N:15]=2)[CH2:21][CH2:22]1)=[O:6]

Participants

3

Reactant 2

HCID 118962,4-Dibromobenzoic acidHCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

Product 1

HCID 71251897(2,4-Dibromophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneYield 85.4%

Procedure

Using 2,4-dibromobenzoic acid (500 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (343 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (691 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 118

Sources & evidence

ORD record
ord-781d6788652040b9b48e76ec35b135f8
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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