3-Chloropropanesulphonyl chloride → Methyl 4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoate

HRID 2411366Notes

Reaction equation

HRID 2411366 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]([Br:12])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].Cl[CH2:14][CH2:15][CH2:16][S:17](Cl)(=[O:19])=[O:18]>>[Br:12][C:10]1[CH:9]=[CH:8][C:3]([C:4]([O:6][CH3:7])=[O:5])=[C:2]([N:1]2[CH2:14][CH2:15][CH2:16][S:17]2(=[O:19])=[O:18])[CH:11]=1

Participants

3

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 17871390Methyl 2-Amino-4-bromobenzoate

Product 1

HCID 58484624Methyl 4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoate

Procedure

Using methyl 2-amino-4-bromobenzoate (5 g) and 3-chloropropane-1-sulfonyl chloride (3.44 mL) and by the reaction and treatment in the same manner as in Preparation Example 17, the title compound (5.32 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 17

Sources & evidence

ORD record
ord-7124ef920c0a4c8fa3fb5d347a110a57
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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