1-Methylimidazolidin-2-one → HCID 71252123, compound

HRID 2411369Notes

Reaction equation

HRID 2411369 reaction equation
Br[C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[C:22]([CH3:23])=[CH:21][C:20]([CH:24]3[CH2:26][CH2:25]3)=[CH:19][N:18]=2)[CH2:13][CH2:12]1)=[O:10].[CH3:27][N:28]1[CH2:32][CH2:31][NH:30][C:29]1=[O:33]>>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[C:22]([CH3:23])=[CH:21][C:20]([CH:24]4[CH2:26][CH2:25]4)=[CH:19][N:18]=3)[CH2:13][CH2:12]2)=[O:10])=[C:2]([N:30]2[CH2:31][CH2:32][N:28]([CH3:27])[C:29]2=[O:33])[CH:7]=1

Participants

3

Reactant 2

HCID 5676001-Methylimidazolidin-2-oneHCID 58484687HCID 58484687, compound

Product 1

HCID 71252123HCID 71252123, compoundYield 28.2%

Procedure

Using (2-bromo-4-chlorophenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (848 mg) described in Preparation Example 235 and 1-methylimidazolidin-2-one (293 mg) and by the reaction and treatment in the same manner as in Preparation Example 241, the title compound (250 mg) was obtained.

Sources & evidence

ORD record
ord-f260f47f0e054785bdf8b4cc9e7d4ec3
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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