5-Bromopyrazine-2-carboxylic acid → HCID 86676769, compound

HRID 2411370Notes

Reaction equation

HRID 2411370 reaction equation
[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH:11]1([C:14]2[CH:15]=[C:16]([CH3:26])[C:17]([N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)=[N:18][CH:19]=2)[CH2:13][CH2:12]1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([N:23]2[CH2:24][CH2:25][N:20]([C:17]3[C:16]([CH3:26])=[CH:15][C:14]([CH:11]4[CH2:12][CH2:13]4)=[CH:19][N:18]=3)[CH2:21][CH2:22]2)=[O:10])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 187797905-Bromopyrazine-2-carboxylic acidHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

Product 1

HCID 86676769HCID 86676769, compoundYield 65.6%

Procedure

Using 5-bromopyrazine-2-carboxylic acid (1 g) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (1.07 g) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (1.3 g) was obtained.

Workup

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 118

Sources & evidence

ORD record
ord-b7b2fca0d1164dc8ab30fd4099a47bfa
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…