1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 71577776, compound

HRID 2411374Notes

Reaction equation

HRID 2411374 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([CH3:11])[N:3]=1.[CH3:12][C:13]1[C:14]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:15][CH:16]=[C:17]([CH3:19])[CH:18]=1>>[Br:1][C:2]1[N:3]=[C:4]([CH3:11])[C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[C:13]([CH3:12])=[CH:18][C:17]([CH3:19])=[CH:16][N:15]=3)[CH2:21][CH2:22]2)=[O:8])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 716915676-BroMo-2-Methyl-nicotinic acid

Product 1

HCID 71577776HCID 71577776, compoundYield 50.8%

Procedure

Using 6-bromo-2-methylnicotinic acid (986 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (917 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (903 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 111

Sources & evidence

ORD record
ord-2fb2964f36c644fa88b6bdf0679733cd
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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