4-Bromo-2-methylbenzoic acid → (4-Bromo-2-methylphenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

HRID 2411380Notes

Reaction equation

HRID 2411380 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([CH3:11])[CH:3]=1.[CH2:12]([C:14]1[CH:15]=[C:16]([CH3:26])[C:17]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:18][CH:19]=1)[CH3:13]>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:17]3[C:16]([CH3:26])=[CH:15][C:14]([CH2:12][CH3:13])=[CH:19][N:18]=3)[CH2:21][CH2:22]2)=[O:8])=[C:4]([CH3:11])[CH:3]=1

Participants

3

Reactant 2

HCID 995704-Bromo-2-methylbenzoic acidHCID 584845781-(5-Ethyl-3-methylpyridin-2-yl)piperazine

Product 1

HCID 58484569(4-Bromo-2-methylphenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneYield 85%

Procedure

Using 4-bromo-2-methylbenzoic acid (1.42 g) and 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (1.23 g) described in Preparation Example 81 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (2.05 g) was obtained.

Workup

  1. customdescribed in Preparation Example 81 and by the reaction and treatment in the same manner as in Preparation Example 111

Sources & evidence

ORD record
ord-47090112955c41ed878b6d3522a7881a
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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