2,4-Imidazolidinedione, 3-methyl- → HCID 71253013, compound

HRID 2411383Notes

Reaction equation

HRID 2411383 reaction equation
Br[C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[CH:19][N:18]=2)[CH2:13][CH2:12]1)=[O:10].[CH3:25][N:26]1[C:30](=[O:31])[CH2:29][NH:28][C:27]1=[O:32]>>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[CH:19][N:18]=3)[CH2:13][CH2:12]2)=[O:10])=[C:2]([N:28]2[CH2:29][C:30](=[O:31])[N:26]([CH3:25])[C:27]2=[O:32])[CH:7]=1

Participants

3

Reactant 2

HCID 1388512,4-Imidazolidinedione, 3-methyl-HCID 58484730(2-Bromo-4-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71253013HCID 71253013, compoundYield 35.1%

Procedure

Using (2-bromo-4-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (817 mg) described in Preparation Example 167 and 3-methylimidazolidine-2,4-dione (339 mg) described in Preparation Example 214 and by the reaction and treatment in the same manner as in Preparation Example 241, the title compound (310 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 214 and by the reaction and treatment in the same manner as in Preparation Example 241

Sources & evidence

ORD record
ord-7556ad80b9f84cd6bd1bc463853615b4
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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