N-Acetylimidazolidinone → HCID 71252060, compound

HRID 2411385Notes

Reaction equation

Br[C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[C:19]([CH3:25])[N:18]=2)[CH2:13][CH2:12]1)=[O:10].[C:26]([N:29]1[CH2:33][CH2:32][NH:31][C:30]1=[O:34])(=[O:28])[CH3:27]>>[C:26]([N:29]1[CH2:33][CH2:32][N:31]([C:2]2[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=2[C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[C:19]([CH3:25])[N:18]=3)[CH2:13][CH2:12]2)=[O:10])[C:30]1=[O:34])(=[O:28])[CH3:27]

Participants

Reactant 2

HCID 79350N-Acetylimidazolidinone

HCID 71253010HCID 71253010, compound

Product 1

HCID 71252060HCID 71252060, compoundYield 61.6%

Procedure

Using (2-bromo-4-chlorophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (846 mg) described in Preparation Example 257 and 1-acetylimidazolidin-2-one (384 mg) and by the reaction and treatment in the same manner as in Preparation Example 234, the title compound (579 mg) was obtained.

Sources & evidence

ORD record: ord-77933453f84c45d9b31df094f0c176f8
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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