1-Methylimidazolidin-2-one → HCID 71251926, compound

HRID 2411386Notes

Reaction equation

HRID 2411386 reaction equation
Br[C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[C:19]([CH3:25])[N:18]=2)[CH2:13][CH2:12]1)=[O:10].[CH3:26][N:27]1[CH2:31][CH2:30][NH:29][C:28]1=[O:32]>>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[C:19]([CH3:25])[N:18]=3)[CH2:13][CH2:12]2)=[O:10])=[C:2]([N:29]2[CH2:30][CH2:31][N:27]([CH3:26])[C:28]2=[O:32])[CH:7]=1

Participants

3

Reactant 2

HCID 5676001-Methylimidazolidin-2-oneHCID 71253010HCID 71253010, compound

Product 1

HCID 71251926HCID 71251926, compoundYield 12.8%

Procedure

Using (2-bromo-4-chlorophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (846 mg) described in Preparation Example 257 and 1-methylimidazolidin-2-one (300 mg) and by the reaction and treatment in the same manner as in Preparation Example 241, the title compound (113 mg) was obtained.

Sources & evidence

ORD record
ord-53f6a2748ab94ae281771919d6f8941d
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…