(4-Bromo-2-methanesulfonylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone → HCID 71252912, compound

HRID 2411391Notes

Reaction equation

HRID 2411391 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([S:24]([CH3:27])(=[O:26])=[O:25])[CH:3]=1.[CH2:28]([C@@H:30]1[CH2:34][CH2:33][S:32](=[O:36])(=[O:35])[NH:31]1)[CH3:29]>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:6]=[CH:7][C:2]([N:31]4[C@H:30]([CH2:28][CH3:29])[CH2:34][CH2:33][S:32]4(=[O:36])=[O:35])=[CH:3][C:4]=3[S:24]([CH3:27])(=[O:26])=[O:25])=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

Participants

3

Reactant 2

HCID 58484505(4-Bromo-2-methanesulfonylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 86676750HCID 86676750, compound

Product 1

HCID 71252912HCID 71252912, compoundYield 25.4%

Procedure

Using (4-bromo-2-methanesulfonylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (664 mg) described in Preparation Example 112 and (R)-3-ethylisothiazolidine 1,1-dioxide (238 mg) described in Preparation Example 3 and by the reaction and treatment in the same manner as in Example 1, the title compound (194 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 3 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-f9f743d5bd874321b4b68c6fbb8957ac
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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