(4-Bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone → HCID 71252513, compound

HRID 2411395Notes

Reaction equation

HRID 2411395 reaction equation
[CH3:1][CH:2]1[S:6](=[O:8])(=[O:7])[NH:5][CH2:4][CH2:3]1.Br[C:10]1[CH:15]=[CH:14][C:13]([C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][C:25]=3[CH3:31])[CH2:20][CH2:19]2)=[O:17])=[C:12]([S:32]([CH3:35])(=[O:34])=[O:33])[CH:11]=1>>[CH3:31][C:25]1[CH:26]=[C:27]([CH3:30])[CH:28]=[CH:29][C:24]=1[N:21]1[CH2:20][CH2:19][N:18]([C:16]([C:13]2[CH:14]=[CH:15][C:10]([N:5]3[CH2:4][CH2:3][CH:2]([CH3:1])[S:6]3(=[O:8])=[O:7])=[CH:11][C:12]=2[S:32]([CH3:35])(=[O:34])=[O:33])=[O:17])[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 58484856(4-Bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanoneHCID 85960151Isothiazolidine, 5-methyl-, 1,1-dioxide

Product 1

HCID 71252513HCID 71252513, compoundYield 21.2%

Procedure

Using 5-methylisothiazolidine 1,1-dioxide (360 mg) described in Preparation Example 5 and (4-bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (803 mg) described in Preparation Example 110 and by the reaction and treatment in the same manner as in Example 4, the title compound (191 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 110 and by the reaction and treatment in the same manner as in Example 4

Sources & evidence

ORD record
ord-5c95d9b4df97420f98e96ed8c9563c61
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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