HuagongsheHuagongshe Chemistry Print Report · For research reference only
[4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone → (S)-[4-(2,4-dimethylphenyl)piperazin-1-yl][4-(3-isopropyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone | HCID 58484733 | — |
| Reactant | (S)-3-isopropylisothiazolidine 1,1-dioxide | HCID 86676751 | — |
| Product | (S)-[4-(2,4-dimethylphenyl)piperazin-1-yl][4-(3-isopropyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl]methanone | HCID 71252932 | 23.5% |
Reaction Steps
Using (S)-3-isopropylisothiazolidine 1,1-dioxide (320 mg) described in Preparation Example 6 and [4-(2,4-dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone (420 mg) described in Preparation Example 108 and by the reaction and treatment in the same manner as in Example 1, the title compound (107 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-4c76d6fcf3314d768abbdeb8291658fe |
| Source note | uspto-grants-2014_08 |