(6-Bromopyridin-3-yl)[4-(4-chlorobenzoyl)piperidin-1-yl]methanone → (S)-[4-(4-chlorobenzoyl)piperidin-1-yl][6-(3-isopropyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl]methanone

Participants

Reaction Steps

Using (S)-3-isopropylisothiazolidine 1,1-dioxide (320 mg) described in Preparation Example 6 and (6-bromopyridin-3-yl)[4-(4-chlorobenzoyl)piperidin-1-yl]methanone (408 mg) described in Preparation Example 190 and by the reaction and treatment in the same manner as in Example 4, the title compound (126 mg) was obtained.

Provenance & Evidence