HuagongsheHuagongshe Chemistry Print Report · For research reference only
[4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone → (R)-[4-(2,4-dimethylphenyl)piperazin-1-yl][4-(4-methyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone | HCID 58484733 | — |
| Reactant | (R)-4-methylisothiazolidine 1,1-dioxide | HCID 86676775 | — |
| Product | (R)-[4-(2,4-dimethylphenyl)piperazin-1-yl][4-(4-methyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl]methanone | HCID 71251944 | 9.1% |
Reaction Steps
Using (R)-4-methylisothiazolidine 1,1-dioxide (203 mg) described in Preparation Example 7 and [4-(2,4-dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone (420 mg) described in Preparation Example 108 and by the reaction and treatment in the same manner as in Example 1, the title compound (39 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-50261e38e8d741f3a8407c719589a5ab |
| Source note | uspto-grants-2014_08 |