[4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone → HCID 71252697, compound

HRID 2411405Notes

Reaction equation

HRID 2411405 reaction equation
[CH:1]([C@H:4]1[CH2:8][CH2:7][S:6](=[O:10])(=[O:9])[NH:5]1)([CH3:3])[CH3:2].[CH3:11][C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[N:19]1[CH2:24][CH2:23][N:22]([C:25]([C:27]2[CH:32]=[CH:31][C:30](I)=[CH:29][CH:28]=2)=[O:26])[CH2:21][CH2:20]1>>[CH3:11][C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[N:19]1[CH2:20][CH2:21][N:22]([C:25]([C:27]2[CH:32]=[CH:31][C:30]([N:5]3[C@@H:4]([CH:1]([CH3:3])[CH3:2])[CH2:8][CH2:7][S:6]3(=[O:10])=[O:9])=[CH:29][CH:28]=2)=[O:26])[CH2:23][CH2:24]1

Participants

3

Reactant 2

HCID 58484733[4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanoneHCID 86676752HCID 86676752, compound

Product 1

HCID 71252697HCID 71252697, compoundYield 4.2%

Procedure

Using (R)-3-isopropylisothiazolidine 1,1-dioxide (300 mg) described in Preparation Example 8 and [4-(2,4-dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone (420 mg) described in Preparation Example 108 and by the reaction and treatment in the same manner as in Example 1, the title compound (19 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 108 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-50f8d111a63f4b1fab72a1650cb43b45
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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