Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone → (S)-[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl][2-fluoro-4-(4-methyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl]methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484626 | — |
| 반응물 | (S)-4-methylisothiazolidine 1,1-dioxide | HCID 86676774 | — |
| 생성물 | (S)-[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl][2-fluoro-4-(4-methyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl]methanone | HCID 71252148 | 17.6% |
반응 단계
Using (S)-4-methylisothiazolidine 1,1-dioxide (150 mg) described in Preparation Example 4 and (4-bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (219 mg) described in Preparation Example 114 and by the reaction and treatment in the same manner as in Example 4, the title compound (44 mg) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08816079B2 |
| 출처 데이터셋 | uspto-grants-2014_08 |
| ORD ID | ord-8121daddbf1d40dc851aba81963414a8 |
| 출처 메모 | uspto-grants-2014_08 |