HRID2411411

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16664117

未命名化合物

结构：Cc1ccc(N2CCN(C(=O)c3ccc(Br)cc3S(C)(=O)=O)CC2)c(C)c1

HCID58484856

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(N2CCN(C(=O)c3ccc(N4[C@H](COCc5ccccc5)CCS4(=O)=O)cc3S(C)(=O)=O)CC2)c(C)c1

HCID71252629

未命名化合物

收率 70.1%

PROCEDURE

实验过程

Using (S)-3-benzyloxymethylisothiazolidine 1,1-dioxide (536 mg) described in Preparation Example 1 and (4-bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (1.0 g) described in Preparation Example 110 and by the reaction and treatment in the same manner as in Example 4, the title compound (950 mg) was obtained.

WORKUP

后处理

customdescribed in Preparation Example 110 and by the reaction and treatment in the same manner as in Example 4

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-be0226224973498498085d22db5ab34e
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08816079B2
来源说明: uspto-grants-2014_08

反应 SMILES

[CH2:1]([O:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[NH:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[C:18]1[CH:23]=[CH:22][C:21]([C:24]([N:26]2[CH2:31][CH2:30][N:29]([C:32]3[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][C:33]=3[CH3:39])[CH2:28][CH2:27]2)=[O:25])=[C:20]([S:40]([CH3:43])(=[O:42])=[O:41])[CH:19]=1>>[CH2:1]([O:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[N:11]1[C:18]1[CH:23]=[CH:22][C:21]([C:24]([N:26]2[CH2:27][CH2:28][N:29]([C:32]3[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][C:33]=3[CH3:39])[CH2:30][CH2:31]2)=[O:25])=[C:20]([S:40]([CH3:43])(=[O:41])=[O:42])[CH:19]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1