HRID2411415

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16664117

未命名化合物

结构：Cc1ccc(N2CCN(C(=O)c3ccc(Br)nc3)CC2)c(C)c1

HCID58484755

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(N2CCN(C(=O)c3ccc(N4[C@H](COCc5ccccc5)CCS4(=O)=O)nc3)CC2)c(C)c1

HCID71252888

未命名化合物

收率 61.4%

PROCEDURE

实验过程

Using (S)-3-benzyloxymethylisothiazolidine 1,1-dioxide (536 mg) described in Preparation Example 1 and (6-bromopyridin-3-yl) [4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (831 mg) described in Preparation Example 115 and by the reaction and treatment in the same manner as in Example 4, the title compound (729 mg) was obtained.

WORKUP

后处理

customdescribed in Preparation Example 115 and by the reaction and treatment in the same manner as in Example 4

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-96806db58c724d0c83bf4f051f27bd4e
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08816079B2
来源说明: uspto-grants-2014_08

反应 SMILES

[CH2:1]([O:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[NH:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[C:18]1[N:23]=[CH:22][C:21]([C:24]([N:26]2[CH2:31][CH2:30][N:29]([C:32]3[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][C:33]=3[CH3:39])[CH2:28][CH2:27]2)=[O:25])=[CH:20][CH:19]=1>>[CH2:1]([O:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[N:11]1[C:18]1[N:23]=[CH:22][C:21]([C:24]([N:26]2[CH2:27][CH2:28][N:29]([C:32]3[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][C:33]=3[CH3:39])[CH2:30][CH2:31]2)=[O:25])=[CH:20][CH:19]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1