HRID2411416

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16664117

未命名化合物

结构：Cc1ccc(N2CCN(C(=O)c3ccc(I)cc3)CC2)c(C)c1

HCID58484733

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(N2CCN(C(=O)c3ccc(N4[C@H](COCc5ccccc5)CCS4(=O)=O)cc3)CC2)c(C)c1

HCID71251886

未命名化合物

收率 88.6%

PROCEDURE

实验过程

Using (S)-3-benzyloxymethylisothiazolidine 1,1-dioxide (536 mg) described in Preparation Example 1 and [4-(2,4-dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone (933 mg) described in Preparation Example 108 and by the reaction and treatment in the same manner as in Example 1, (S)-[4-(3-benzyloxymethyl-1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl][4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (1.05 g) was obtained. Using the obtained (S)-[4-(3-benzyloxymethyl-1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl][4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (1.05 g) and by the reaction and treatment in the same manner as in Example 29, the title compound (590 mg) was obtained.

WORKUP

后处理

customdescribed in Preparation Example 108 and by the reaction and treatment in the same manner as in Example 1

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fedf2dc283b04f4b811a0d2a75b34ea9
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08816079B2
来源说明: uspto-grants-2014_08

反应 SMILES

[CH2:1]([O:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[NH:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17][C:18]1[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][C:19]=1[N:25]1[CH2:30][CH2:29][N:28]([C:31]([C:33]2[CH:38]=[CH:37][C:36](I)=[CH:35][CH:34]=2)=[O:32])[CH2:27][CH2:26]1>>[CH2:1]([O:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[N:11]1[C:36]1[CH:35]=[CH:34][C:33]([C:31]([N:28]2[CH2:27][CH2:26][N:25]([C:19]3[CH:20]=[CH:21][C:22]([CH3:24])=[CH:23][C:18]=3[CH3:17])[CH2:30][CH2:29]2)=[O:32])=[CH:38][CH:37]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1