HRID2411423

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16664117

未命名化合物

结构：O=C(c1ccc(I)cc1F)N1CCN(c2ncc(C3CC3)cc2C2CC2)CC1

HCID71251940

未命名化合物

PRODUCTS

生成物

结构：O=C(c1ccc(N2[C@H](CO)CCS2(=O)=O)cc1F)N1CCN(c2ncc(C3CC3)cc2C2CC2)CC1

HCID71252943

未命名化合物

收率 43.6%

PROCEDURE

实验过程

Using (S)-3-benzyloxymethylisothiazolidine 1,1-dioxide (393 mg) described in Preparation Example 1 and [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](2-fluoro-4-iodophenyl)methanone (800 mg) described in Preparation Example 164 and by the reaction and treatment in the same manner as in Example 32, the title compound (365 mg) was obtained.

WORKUP

后处理

customdescribed in Preparation Example 164 and by the reaction and treatment in the same manner as in Example 32

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9caac7d17dd24736a37f84d486521917
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08816079B2
来源说明: uspto-grants-2014_08

反应 SMILES

C([O:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[NH:11]1)C1C=CC=CC=1.[CH:17]1([C:20]2[C:21]([N:29]3[CH2:34][CH2:33][N:32]([C:35]([C:37]4[CH:42]=[CH:41][C:40](I)=[CH:39][C:38]=4[F:44])=[O:36])[CH2:31][CH2:30]3)=[N:22][CH:23]=[C:24]([CH:26]3[CH2:28][CH2:27]3)[CH:25]=2)[CH2:19][CH2:18]1>>[CH:17]1([C:20]2[C:21]([N:29]3[CH2:30][CH2:31][N:32]([C:35]([C:37]4[CH:42]=[CH:41][C:40]([N:11]5[C@H:10]([CH2:9][OH:8])[CH2:14][CH2:13][S:12]5(=[O:15])=[O:16])=[CH:39][C:38]=4[F:44])=[O:36])[CH2:33][CH2:34]3)=[N:22][CH:23]=[C:24]([CH:26]3[CH2:28][CH2:27]3)[CH:25]=2)[CH2:18][CH2:19]1