[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone → HCID 71252693, compound

HRID 2411424Notes

Reaction equation

HRID 2411424 reaction equation
[CH3:1][C@@H:2]1[CH2:6][S:5](=[O:8])(=[O:7])[NH:4][CH2:3]1.[CH:9]1([C:12]2[CH:13]=[C:14]([CH3:33])[C:15]([N:18]3[CH2:23][CH2:22][N:21]([C:24]([C:26]4[CH:31]=[CH:30][C:29](I)=[CH:28][CH:27]=4)=[O:25])[CH2:20][CH2:19]3)=[N:16][CH:17]=2)[CH2:11][CH2:10]1>>[CH:9]1([C:12]2[CH:13]=[C:14]([CH3:33])[C:15]([N:18]3[CH2:23][CH2:22][N:21]([C:24]([C:26]4[CH:31]=[CH:30][C:29]([N:4]5[CH2:3][C@H:2]([CH3:1])[CH2:6][S:5]5(=[O:8])=[O:7])=[CH:28][CH:27]=4)=[O:25])[CH2:20][CH2:19]3)=[N:16][CH:17]=2)[CH2:10][CH2:11]1

Participants

3

Reactant 2

HCID 58484841[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanoneHCID 86676774(S)-4-methylisothiazolidine 1,1-dioxide

Product 1

HCID 71252693HCID 71252693, compoundYield 40%

Procedure

Using (S)-4-methylisothiazolidine 1,1-dioxide (240 mg) described in Preparation Example 4 and [4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (650 mg) described in Preparation Example 117 and by the reaction and treatment in the same manner as in Example 1, the title compound (264 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 117 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-fa1a16feabc34bc49b8b99a3d719dcce
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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