(4-Bromo-2-methanesulfonylphenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone → (S)-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl][2-methanesulfonyl-4-(4-methyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl]methanone

Participants

Reaction Steps

Using (S)-4-methylisothiazolidine 1,1-dioxide (140 mg) described in Preparation Example 4 and (4-bromo-2-methanesulfonylphenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (330 mg) described in Preparation Example 126 and by the reaction and treatment in the same manner as in Example 4, the title compound (148 mg) was obtained.

Provenance & Evidence