(4-Bromo-2-methanesulfonylphenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone → (S)-[2-methanesulfonyl-4-(4-methyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl][4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

Participants

Reaction Steps

Using (S)-4-methylisothiazolidine 1,1-dioxide (110 mg) described in Preparation Example 4 and (4-bromo-2-methanesulfonylphenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (253 mg) described in Preparation Example 122 and by the reaction and treatment in the same manner as in Example 4, the title compound (151 mg) was obtained.

Provenance & Evidence