(4-Bromo-2-fluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone → HCID 71252910, compound

HRID 2411438Notes

Reaction equation

HRID 2411438 reaction equation
[CH3:1][C@@H:2]1[CH2:6][S:5](=[O:8])(=[O:7])[NH:4][CH2:3]1.Br[C:10]1[CH:15]=[CH:14][C:13]([C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][C:25]=3[CH3:31])[CH2:20][CH2:19]2)=[O:17])=[C:12]([F:32])[CH:11]=1>>[CH3:31][C:25]1[CH:26]=[C:27]([CH3:30])[CH:28]=[CH:29][C:24]=1[N:21]1[CH2:20][CH2:19][N:18]([C:16]([C:13]2[CH:14]=[CH:15][C:10]([N:4]3[CH2:3][C@H:2]([CH3:1])[CH2:6][S:5]3(=[O:8])=[O:7])=[CH:11][C:12]=2[F:32])=[O:17])[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 58484705(4-Bromo-2-fluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanoneHCID 86676774(S)-4-methylisothiazolidine 1,1-dioxide

Product 1

HCID 71252910HCID 71252910, compoundYield 27.8%

Procedure

Using (S)-4-methylisothiazolidine 1,1-dioxide (101 mg) described in Preparation Example 4 and (4-bromo-2-fluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (196 mg) described in Preparation Example 116 and by the reaction and treatment in the same manner as in Example 4, the title compound (62 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 116 and by the reaction and treatment in the same manner as in Example 4

Sources & evidence

ORD record
ord-a6bf86b3632d499c81205d580507bddf
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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