HCID 58484755, compound → HCID 71252196, compound

HRID 2411440Notes

Reaction equation

HRID 2411440 reaction equation
[CH3:1][C@@H:2]1[CH2:6][S:5](=[O:8])(=[O:7])[NH:4][CH2:3]1.Br[C:10]1[N:15]=[CH:14][C:13]([C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][C:25]=3[CH3:31])[CH2:20][CH2:19]2)=[O:17])=[CH:12][CH:11]=1>>[CH3:31][C:25]1[CH:26]=[C:27]([CH3:30])[CH:28]=[CH:29][C:24]=1[N:21]1[CH2:20][CH2:19][N:18]([C:16]([C:13]2[CH:14]=[N:15][C:10]([N:4]3[CH2:3][C@H:2]([CH3:1])[CH2:6][S:5]3(=[O:8])=[O:7])=[CH:11][CH:12]=2)=[O:17])[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 58484755HCID 58484755, compoundHCID 86676774(S)-4-methylisothiazolidine 1,1-dioxide

Product 1

HCID 71252196HCID 71252196, compoundYield 42%

Procedure

Using (S)-4-methylisothiazolidine 1,1-dioxide (203 mg) described in Preparation Example 4 and (6-bromopyridin-3-yl) [4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (374 mg) described in Preparation Example 115 and by the reaction and treatment in the same manner as in Example 1, the title compound (180 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 115 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-89813b97d3b44a51af758e6b4f75c27a
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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