(S)-3-benzyloxymethylisothiazolidine 1,1-dioxide → HCID 71252035, compound

HRID 2411444Notes

Reaction equation

HRID 2411444 reaction equation
C([O:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[NH:11]1)C1C=CC=CC=1.Br[C:18]1[CH:23]=[CH:22][C:21]([C:24]([N:26]2[CH2:31][CH2:30][N:29]([C:32]3[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][C:33]=3[CH3:39])[CH2:28][CH2:27]2)=[O:25])=[C:20]([CH3:40])[CH:19]=1>>[CH3:39][C:33]1[CH:34]=[C:35]([CH3:38])[CH:36]=[CH:37][C:32]=1[N:29]1[CH2:30][CH2:31][N:26]([C:24]([C:21]2[CH:22]=[CH:23][C:18]([N:11]3[C@H:10]([CH2:9][OH:8])[CH2:14][CH2:13][S:12]3(=[O:15])=[O:16])=[CH:19][C:20]=2[CH3:40])=[O:25])[CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 16664117(S)-3-benzyloxymethylisothiazolidine 1,1-dioxideHCID 58484788HCID 58484788, compound

Product 1

HCID 71252035HCID 71252035, compoundYield 72.4%

Procedure

Using (S)-3-benzyloxymethylisothiazolidine 1,1-dioxide (482 mg) described in Preparation Example 1 and (4-bromo-2-methylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (774 mg) described in Preparation Example 130 and by the reaction and treatment in the same manner as in Example 32, the title compound (662 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 130 and by the reaction and treatment in the same manner as in Example 32

Sources & evidence

ORD record
ord-c53ed4c36a544dc69d502dd1829c3ce6
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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