HCID 16664117, compound → HCID 71252130, compound

HRID 2411445Notes

Reaction equation

HRID 2411445 reaction equation
C([O:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[NH:11]1)C1C=CC=CC=1.Br[C:18]1[CH:23]=[C:22]([F:24])[C:21]([C:25]([N:27]2[CH2:32][CH2:31][N:30]([C:33]3[CH:38]=[CH:37][C:36]([CH3:39])=[CH:35][C:34]=3[CH3:40])[CH2:29][CH2:28]2)=[O:26])=[C:20]([F:41])[CH:19]=1>>[F:41][C:20]1[CH:19]=[C:18]([N:11]2[C@H:10]([CH2:9][OH:8])[CH2:14][CH2:13][S:12]2(=[O:15])=[O:16])[CH:23]=[C:22]([F:24])[C:21]=1[C:25]([N:27]1[CH2:32][CH2:31][N:30]([C:33]2[CH:38]=[CH:37][C:36]([CH3:39])=[CH:35][C:34]=2[CH3:40])[CH2:29][CH2:28]1)=[O:26]

Participants

3

Reactant 2

HCID 16664117HCID 16664117, compoundHCID 58484529HCID 58484529, compound

Product 1

HCID 71252130HCID 71252130, compoundYield 52%

Procedure

Using (S)-3-benzyloxymethylisothiazolidine 1,1-dioxide (482 mg) described in Preparation Example 1 and (4-bromo-2,6-difluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (819 mg) described in Preparation Example 109 and by the reaction and treatment in the same manner as in Example 32, the title compound (498 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 109 and by the reaction and treatment in the same manner as in Example 32

Sources & evidence

ORD record
ord-3955a11e77a14b13b7693fec8f36e153
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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