HCID 16664117, compound → HCID 71252651, compound

HRID 2411446Notes

Reaction equation

HRID 2411446 reaction equation
C([O:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[NH:11]1)C1C=CC=CC=1.Br[C:18]1[CH:23]=[CH:22][C:21]([C:24]([N:26]2[CH2:31][CH2:30][N:29]([C:32]3[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][C:33]=3[CH3:39])[CH2:28][CH2:27]2)=[O:25])=[C:20]([Cl:40])[CH:19]=1>>[Cl:40][C:20]1[CH:19]=[C:18]([N:11]2[C@H:10]([CH2:9][OH:8])[CH2:14][CH2:13][S:12]2(=[O:15])=[O:16])[CH:23]=[CH:22][C:21]=1[C:24]([N:26]1[CH2:31][CH2:30][N:29]([C:32]2[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][C:33]=2[CH3:39])[CH2:28][CH2:27]1)=[O:25]

Participants

3

Reactant 2

HCID 16664117HCID 16664117, compoundHCID 58484715HCID 58484715, compound

Product 1

HCID 71252651HCID 71252651, compoundYield 22.8%

Procedure

Using (S)-3-benzyloxymethylisothiazolidine 1,1-dioxide (586 mg) described in Preparation Example 1 and (4-bromo-2-chlorophenyl) [4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (990 mg) described in Preparation Example 131 and by the reaction and treatment in the same manner as in Example 32, the title compound (265 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 131 and by the reaction and treatment in the same manner as in Example 32

Sources & evidence

ORD record
ord-bf6ce5c87269489f84a035f950a61543
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…